Amylin (rat)

Modify Date: 2024-01-08 08:21:34

Amylin (rat) Structure
Amylin (rat) structure
Common Name Amylin (rat)
CAS Number 124447-81-0 Molecular Weight 3920.44
Density N/A Boiling Point N/A
Molecular Formula C167H272N52O53S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amylin (rat)


Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.

 Names

Name Amylin, amide, rat

 Amylin (rat) Biological Activity

Description Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.
Related Catalog
Target

Amylin receptor AMY1 and AMY3[1]

In Vitro Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. Amylin is a member of the calcitonin (CT) family of peptides, which includes CT itself, the CGRPs comprising two variants (αCGRP and βCGRP), adrenomedullin (AM) and AM2 (intermedin). Amylin is a centrally acting, neuroendocrine hormone synthesized with insulin in the beta cells of pancreatic islets. Amylin regulates glucose homeostasis by inhibiting gastric emptying, inhibiting the release of the counter-regulatory hormone glucagon and inducing meal-ending satiety. Amylin functions as a glucoregulatory and satiety-inducing hormone, which is protective against postprandial spikes in blood glucose and overeating.[1]
References

[1]. Bower RL, et al. Amylin structure-function relationships and receptor pharmacology: implications for Amylin mimetic drug development. Br J Pharmacol. 2016 Jun;173(12):1883-98.

 Chemical & Physical Properties

Molecular Formula C167H272N52O53S2
Molecular Weight 3920.44
Storage condition 2-8℃
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