Spisulosine-d3

Modify Date: 2025-08-28 17:26:57

Spisulosine-d3 Structure
Spisulosine-d3 structure
Common Name Spisulosine-d3
CAS Number 1246298-31-6 Molecular Weight 288.53
Density N/A Boiling Point N/A
Molecular Formula C18H36D3NO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Spisulosine-d3


Spisulosine-d3 is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC

 Names

Name Spisulosine-d3

 Spisulosine-d3 Biological Activity

Description Spisulosine-d3 is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].
References

[1]. Ana M Sánchez, et al. Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584(2-3):237-45.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Molecular Formula C18H36D3NO
Molecular Weight 288.53
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