Fenspiride-d5 hydrochloride

Modify Date: 2024-01-07 22:42:25

Fenspiride-d5 hydrochloride Structure
Fenspiride-d5 hydrochloride structure
Common Name Fenspiride-d5 hydrochloride
CAS Number 1246815-28-0 Molecular Weight 301.82
Density N/A Boiling Point N/A
Molecular Formula C15H16D5ClN2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fenspiride-d5 hydrochloride


Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride. Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist[1][2].

 Names

Name Fenspiride-d5 hydrochloride

 Fenspiride-d5 hydrochloride Biological Activity

Description Fenspiride-d5 hydrochloride is the deuterium labeled Fenspiride hydrochloride. Fenspiride hydrochloride is an α adrenergic and H1 histamine receptor antagonist[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Lebedenko AA, Mal'tsev SV..[The efficacy of application of fenspiride (erespal) for the treatment of exacerbation of bronchial asthma in children.]Vestn Otorinolaringol. 2011;(4):66-67.

[3]. Khawaja AM, Liu YC, Rogers DF. et al.Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm Pharmacol Ther. 1999;12(6):363-8.

[4]. Zielnik-Jurkiewicz B, Jurkiewicz D. et al. Usefulness of fenspiride in the treatment of acute otitis media in children. Pol Merkur Lekarski. 2005 Jun;18(108):624-8.

[5]. Bee D, Laude EA, Emery CJ, Howard P. Effect of fenspiride on pulmonary function in the rat and guinea pig. Clin Sci (Lond). 1995 Mar;88(3):325-30.

[6]. Fenspiride

 Chemical & Physical Properties

Molecular Formula C15H16D5ClN2O2
Molecular Weight 301.82