CFI-400437
Modify Date: 2024-02-26 21:44:45
CFI-400437 structure
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Common Name | CFI-400437 | ||
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| CAS Number | 1247000-76-5 | Molecular Weight | 565.494 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H28N6O2.2HCl | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CFI-400437CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). |
| Name | (3Z)-5-Methoxy-3-[(3-{(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]vinyl}-1H-indazol-6-yl)methylene]-1,3-dihydro-2H-indol-2-one dihydrochloride |
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| Synonym | More Synonyms |
| Description | CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). |
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| In Vitro | CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). Against a broad panel of kinases, only a small subset is significantly inhibited. CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468, and MDA-MB-231 cell growth and very effective in a mouse xenograft model of tumor growth. |
| Molecular Formula | C29H28N6O2.2HCl |
|---|---|
| Molecular Weight | 565.494 |
| Exact Mass | 564.180725 |
| 2H-Indol-2-one, 1,3-dihydro-5-methoxy-3-[[3-[(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]ethenyl]-1H-indazol-6-yl]methylene]-, (3Z)-, hydrochloride (1:2) |
| (3Z)-5-Methoxy-3-[(3-{(E)-2-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]vinyl}-1H-indazol-6-yl)methylene]-1,3-dihydro-2H-indol-2-one dihydrochloride |