N-(hexanoyl)sphing-4-enine

Modify Date: 2025-08-26 00:15:29

N-(hexanoyl)sphing-4-enine structure	Common Name	N-(hexanoyl)sphing-4-enine
	CAS Number	124753-97-5	Molecular Weight	397.63
	Density	0.9±0.1 g/cm3	Boiling Point	574.7±50.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₄₇NO₃	Melting Point	76-77ºC
	MSDS	Chinese USA	Flash Point	301.4±30.1 °C

Use of N-(hexanoyl)sphing-4-enine

C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2].

Name	6-Hexanoyl-D-erythro-sphingosine
Synonym	More Synonyms

Description	C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117. [2]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

References

[1]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117.

[2]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298.

Density	0.9±0.1 g/cm3
Boiling Point	574.7±50.0 °C at 760 mmHg
Melting Point	76-77ºC
Molecular Formula	C₂₄H₄₇NO₃
Molecular Weight	397.63
Flash Point	301.4±30.1 °C
Exact Mass	397.355591
PSA	69.56000
LogP	8.02
Vapour Pressure	0.0±3.6 mmHg at 25°C
Index of Refraction	1.483
InChIKey	NPRJSFWNFTXXQC-UHFFFAOYSA-N
SMILES	CCCCCCCCCCCCCC=CC(O)C(CO)NC(=O)CCCCC
Storage condition	-20°C

N-(hexanoyl)sphing-4-enine MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition.

Am. J. Physiol. Cell Physiol. 309 , C239-50, (2015)

Protein kinase C can activate NADPH oxidase and induce glutathionylation of the β1-Na(+)-K(+) pump subunit, inhibiting activity of the catalytic α-subunit. To examine if signaling of nitric oxide-indu...

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation.

Part. Fibre Toxicol. 9 , 48, (2012)

Particulate air pollution in lung epithelial cells induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions. The activation of the epidermal growth factor receptor (E...

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.

J. Exp. Clin. Cancer Res 34 , 94, (2015)

Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficie...

Name: Cytotoxicity against human A549 cells upto 1 mM in presence of <=5% FBS after 72 hrs ...
Source: ChEMBL
Target: A549
External Id: CHEMBL916508

Name: Cytotoxicity against human A549 cells in presence of 10% FBS after 72 hrs by MTT test
Source: ChEMBL
Target: A549
External Id: CHEMBL916509

Name: Cytotoxicity against human A549 cells after 72 hrs by MTT test
Source: ChEMBL
Target: A549
External Id: CHEMBL916510

Name: Metabolic stability in human MCF7 cells assessed as endogenous sphingosine levels at ...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL1273860

Name: A screen for small molecules that modulate mitochondrial supercomplex formation
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1482

Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE

Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE

Name: Metabolic stability in human MCF7 cells assessed as C18-ceramide levels at 20 uM afte...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL1272408

Name: Metabolic stability in human MCF7 cells assessed as C14-ceramide levels at 20 uM afte...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL1272409

Name: Cytotoxicity against human SupT1 cells after 24 hrs by CellTiter-Blue assay
Source: ChEMBL
Target: SUP-T1
External Id: CHEMBL1034069

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N-Hexanoyl-D-sphingosine

N-hexanoyl-D-erythro-sphingosine

C6 ceramide Caproyl ceramide N-Caproyl-D-sphingosine

N-(hexanoyl)sphing-4-enine

N-(hexanoyl)-sphing-4-enine

MFCD00870174

N-[(2S,3R,4E)-1,3-Dihydroxy-4-octadecen-2-yl]hexanamide

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Product Name: N-hexanoyl-D-erythro-sphingosine
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.