Ganirelix Acetate

Modify Date: 2024-01-06 19:04:48

Ganirelix Acetate Structure
Ganirelix Acetate structure
Common Name Ganirelix Acetate
CAS Number 129311-55-3 Molecular Weight 1690.423
Density N/A Boiling Point N/A
Molecular Formula C84H121ClN18O17 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Ganirelix Acetate


Ganirelix acetate (Ganirest) is an injectable competitive gonadotropin-releasing hormone (GnRH) antagonist. Ganirelix acetate directly competes against the endogenous molecule for receptor binding, and causes a rapid reduction in estradiol levels. Ganirelix acetate can be used for researching ovarian hyperstimulation syndrome (OHSS)[1].

 Names

Name Ganirelix acetate
Synonym More Synonyms

 Ganirelix Acetate Biological Activity

Description Ganirelix acetate (Ganirest) is an injectable competitive gonadotropin-releasing hormone (GnRH) antagonist. Ganirelix acetate directly competes against the endogenous molecule for receptor binding, and causes a rapid reduction in estradiol levels. Ganirelix acetate can be used for researching ovarian hyperstimulation syndrome (OHSS)[1].
Related Catalog
Target

GnRH[1]

References

[1]. Gustofson RL, et al. Ganirelix acetate causes a rapid reduction in estradiol levels without adversely affecting oocyte maturation in women pretreated with leuprolide acetate who are at risk of ovarian hyperstimulation syndrome. Hum Reprod. 2006 Nov;21(11):2830-7.

 Chemical & Physical Properties

Molecular Formula C84H121ClN18O17
Molecular Weight 1690.423
Exact Mass 1688.884521

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
RIDADR NONH for all modes of transport

 Articles27

More Articles
Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors.

Am. J. Physiol. Endocrinol. Metab. 305(7) , E818-25, (2013)

Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises cutaneous microvascular dilation in women with PCO...

GnRH antagonist versus long GnRH agonist protocol in poor IVF responders: a randomized clinical trial.

Eur. J. Obstet. Gynecol. Reprod. Biol. 166(1) , 43-6, (2013)

To compare the efficacy of the long GnRH agonist and the fixed GnRH antagonist protocols in IVF poor responders.This was a randomized controlled trial performed in the Iakentro IVF centre, Thessalonik...

Outpatient management of severe early OHSS by administration of GnRH antagonist in the luteal phase: an observational cohort study.

Reprod. Biol. Endocrinol. 10 , 69, (2012)

Management of established severe OHSS requires prolonged hospitalization, occasionally in intensive care units, accompanied by multiple ascites punctures, correction of intravascular fluid volume and ...

 Synonyms

56U7906FQW
D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]- ;L-lysyl-L-prolyl-, acetate (1:2)
Ganirelix acetate
UNII:56U7906FQW
N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D- ;alaninamide acetate (1:2)
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