RQ 00203078
Modify Date: 2024-02-04 19:04:52
RQ 00203078 structure
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Common Name | RQ 00203078 | ||
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| CAS Number | 1254205-52-1 | Molecular Weight | 554.847 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 602.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C21H13ClF6N2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 317.9±34.3 °C | |
Use of RQ 00203078RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. IC50 value: 5.3 nM (for rat channel), 8.3 nM nM ( for human channel)Target: TRPM8in vitro: RQ-00203078 reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion.in vivo: RQ-00203078 demonstrates excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration and may become an important pharmacological tool for fully assessing the potential therapeutic use of the targets activated by cold stimulation. RQ-00203078 also attenuates icilin-induced wet dog shakes in rats. |
| Name | rq-00203078 |
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| Synonym | More Synonyms |
| Description | RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. IC50 value: 5.3 nM (for rat channel), 8.3 nM nM ( for human channel)Target: TRPM8in vitro: RQ-00203078 reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion.in vivo: RQ-00203078 demonstrates excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats after oral administration and may become an important pharmacological tool for fully assessing the potential therapeutic use of the targets activated by cold stimulation. RQ-00203078 also attenuates icilin-induced wet dog shakes in rats. |
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| Related Catalog |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.0±65.0 °C at 760 mmHg |
| Molecular Formula | C21H13ClF6N2O5S |
| Molecular Weight | 554.847 |
| Flash Point | 317.9±34.3 °C |
| Exact Mass | 554.013794 |
| PSA | 105.18000 |
| LogP | 6.04 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.567 |
| Storage condition | 2-8℃ |
| 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid |
| RQ00203078 |
| 4-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][4-(trifluoromethoxy)benzyl]sulfamoyl}benzoic acid |
| Benzoic acid, 4-[[[3-chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]- |