RQ-00203078

• 常用名: RQ-00203078
• 英文名: RQ 00203078
• CAS号: 1254205-52-1
• 分子量: 554.847
• 密度: 1.6±0.1 g/cm3
• 沸点: 602.0±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₃ClF₆N₂O₅S
• 熔点: N/A
• 闪点: 317.9±34.3 °C

RQ-00203078用途

RQ-00203078是一种口服有效的, 高度选择性TRPM8拮抗剂,作用于鼠和人离子通道, IC50 值分别为5.3 和 8.3 nM。

RQ-00203078名称

• 中文名: RQ-00203078
• 英文名: rq-00203078

RQ-00203078生物活性

• 描述: RQ-00203078是一种口服有效的, 高度选择性TRPM8拮抗剂,作用于鼠和人离子通道, IC50 值分别为5.3 和 8.3 nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 癌症

RQ-00203078物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 602.0±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₃ClF₆N₂O₅S
• 分子量: 554.847
• 闪点: 317.9±34.3 °C
• 精确质量: 554.013794
• PSA: 105.18000
• LogP: 6.04
• InChIKey: IJGQFZYYEHCCIZ-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccc(S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c2ncc(C(F)(F)F)cc2Cl)cc1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 2-8℃

RQ-00203078靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Antagonist activity at TRPM8 (unknown origin) 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8 External Id：CHEMBL5253448

实验名称：In vivo antagonist activity at TRPM8 in po dosed rat assessed as shaking behaviour 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8 External Id：CHEMBL5253447

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Intrinsic clearance in human liver microsomes 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3383301

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition o... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily M member 8 External Id：CHEMBL3383300

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RQ-00203078英文别名

• 4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid
• RQ00203078
• 4-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][4-(trifluoromethoxy)benzyl]sulfamoyl}benzoic acid