Acetyl-Hirudin (54-65) (sulfated)

Modify Date: 2024-01-10 16:07:38

Acetyl-Hirudin (54-65) (sulfated) Structure
Acetyl-Hirudin (54-65) (sulfated) structure
Common Name Acetyl-Hirudin (54-65) (sulfated)
CAS Number 125441-00-1 Molecular Weight 1590.617
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C68H95N13O29S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Acetyl-Hirudin (54-65) (sulfated)


Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

 Names

Name Acetyl-Hirudin (54-65) (sulfated)
Synonym More Synonyms

 Acetyl-Hirudin (54-65) (sulfated) Biological Activity

Description Acetyl-Hirudin (54-65) (sulfated) binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].
Related Catalog
References

[1]. J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272(13):8243-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C68H95N13O29S
Molecular Weight 1590.617
Exact Mass 1589.607910
PSA 679.28000
LogP -0.55
Index of Refraction 1.591

 Synonyms

Glutamine, N-acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucyl-
N-ACETYL-HIRUDIN AC-[TYR(SO3H)63]-FRAGMENT 54-65
acetyl-[tyr(so3h)63]-hirudin fragment 54-65
N-Acetylglycyl-α-aspartylphenylalanyl-α-glutamyl-α-glutamylisoleucylprolyl-α-glutamyl-α-glutamyl-O-sulfotyrosylleucylglutamine
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN-OH
AC-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-GLN
N-acetyl-(tyr(so3H)63)-hirudin *fragment 54-65
ACETYL-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR[SO3H]-LEU-GLN
AC-HIRUDIN (54-65) (SULFATED)