lavendustin B
Modify Date: 2024-01-11 13:50:52
lavendustin B structure
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Common Name | lavendustin B | ||
|---|---|---|---|---|
| CAS Number | 125697-91-8 | Molecular Weight | 365.37900 | |
| Density | 1.423 g/cm3 | Boiling Point | 671.1ºC at 760 mmHg | |
| Molecular Formula | C21H19NO5 | Melting Point | 140-144ºC | |
| MSDS | N/A | Flash Point | 359.7ºC | |
Use of lavendustin BLavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2]. |
| Name | Lavendustin B |
|---|---|
| Synonym | More Synonyms |
| Description | Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2]. |
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| Related Catalog | |
| Target |
GLUT1:15 μM (Ki) HIV-1 integrase interaction with LEDGF/p75:94.07 μM (IC50) |
| In Vitro | In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes[1]. |
| References |
| Density | 1.423 g/cm3 |
|---|---|
| Boiling Point | 671.1ºC at 760 mmHg |
| Melting Point | 140-144ºC |
| Molecular Formula | C21H19NO5 |
| Molecular Weight | 365.37900 |
| Flash Point | 359.7ºC |
| Exact Mass | 365.12600 |
| PSA | 101.23000 |
| LogP | 3.70840 |
| Vapour Pressure | 6.31E-19mmHg at 25°C |
| Index of Refraction | 1.726 |
| 5-[bis[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid |