Clothianidine-d3

Modify Date: 2024-01-03 08:20:59

Clothianidine-d3 Structure
Clothianidine-d3 structure
Common Name Clothianidine-d3
CAS Number 1262776-24-8 Molecular Weight 252.697
Density 1.7±0.1 g/cm3 Boiling Point 435.2±55.0 °C at 760 mmHg
Molecular Formula C6H5ClD3N5O2S Melting Point N/A
MSDS Chinese USA Flash Point 217.0±31.5 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of Clothianidine-d3


Clothianidin-d3 is the deuterium labeled Clothianidin.

 Names

Name 2-[(2-chloro-1,3-thiazol-5-yl)methyl]-1-nitro-3-(trideuteriomethyl)guanidine
Synonym More Synonyms

 Clothianidine-d3 Biological Activity

Description Clothianidin-d3 is the deuterium labeled Clothianidin.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 435.2±55.0 °C at 760 mmHg
Molecular Formula C6H5ClD3N5O2S
Molecular Weight 252.697
Flash Point 217.0±31.5 °C
Exact Mass 252.027557
PSA 123.37000
LogP -0.15
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.709

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
RIDADR UN 3077 9 / PGIII

 Articles4

More Articles
Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.

PLoS ONE 11 , e0146335, (2016)

Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha...

Field-scale examination of neonicotinoid insecticide persistence in soil as a result of seed treatment use in commercial maize (corn) fields in southwestern Ontario.

Environ. Toxicol. Chem. 35 , 295-302, (2016)

Neonicotinoid insecticides, especially as seed treatments, have raised concerns about environmental loading and impacts on pollinators, biodiversity, and ecosystems. The authors measured concentration...

 Synonyms

1-[(2-chlorothiazol-5-yl)methyl]-2-nitro-3-(trideuteriomethyl)guanidine
1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-(H)methyl-3-nitroguanidine
Clothianidin-d3
Clothianidine-d3
(E)-1-(2-Chloro-5-thiazolylmethyl)-3-(methyl-d3)-2-nitroguanidine
Guanidine, N-[(2-chloro-5-thiazolyl)methyl]-N'-methyl-d-N''-nitro-