Rivastigmine (tartrate)
Rivastigmine (tartrate) structure
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Common Name | Rivastigmine (tartrate) | ||
|---|---|---|---|---|
| CAS Number | 129101-54-8 | Molecular Weight | 400.423 | |
| Density | N/A | Boiling Point | 316.2ºC at 760 mmHg | |
| Molecular Formula | C18H28N2O8 | Melting Point | 123-1250C | |
| MSDS | Chinese | Flash Point | 145ºC | |
Use of Rivastigmine (tartrate)Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesteraseIC50 value: 5.5 uMTarget: AChERivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting. The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions. Rivastigmine, a cholinesterase inhibitor, inhibits both butyrylcholinesterase and acetylcholinesterase. It is thought to work by inhibiting these cholinesterase enzymes, which would otherwise break down the brain chemical acetylcholine. |
| Name | rivastigmine tartrate |
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| Synonym | More Synonyms |
| Description | Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesteraseIC50 value: 5.5 uMTarget: AChERivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease. The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, which typically include nausea and vomiting. The drug is eliminated through the urine, and appears to have relatively few drug-drug interactions. Rivastigmine, a cholinesterase inhibitor, inhibits both butyrylcholinesterase and acetylcholinesterase. It is thought to work by inhibiting these cholinesterase enzymes, which would otherwise break down the brain chemical acetylcholine. |
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| Related Catalog | |
| References |
| Boiling Point | 316.2ºC at 760 mmHg |
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| Melting Point | 123-1250C |
| Molecular Formula | C18H28N2O8 |
| Molecular Weight | 400.423 |
| Flash Point | 145ºC |
| Exact Mass | 400.184570 |
| PSA | 147.84000 |
| LogP | 0.63710 |
| Vapour Pressure | 0.000416mmHg at 25°C |
| Storage condition | -20°C Freezer |
| HS Code | 2942000000 |
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[Effect of AChE and BuChE inhibition by rivastigmin in a group of old-old elderly patients with cerebrovascular impairment (SIVD type)].
Minerva Med. 105(2) , 167-74, (2014) Vascular dementia (VaD) is defined as a loss of cognitive function resulting from ischemic, hypoperfusive, or hemorrhagic brain lesions due to cerebrovascular disease or cardiovascular pathology. The ... |
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Blood pro-inflammatory cytokines in Alzheimer's disease in relation to the use of acetylcholinesterase inhibitors.
Int. J. Geriatr. Psychiatry 28(12) , 1312-7, (2013) A potential anti-inflammatory role for acetylcholinesterase inhibitors (AChEIs) has been supported by animal studies. As very limited data exist from individuals with Alzheimer's disease (AD), the aim... |
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Rivastigmine for vascular cognitive impairment.
Cochrane Database Syst. Rev. 5 , CD004744, (2013) Vascular dementia represents the second most common type of dementia after Alzheimer's disease. In older patients, in particular, the combination of vascular dementia and Alzheimer's disease is common... |
| 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate 2,3-dihydroxybutanedioate (1:1) |
| acide (2R,3R)-2,3-dihydroxybutanedioïque - éthyl(méthyl)carbamate de 3-[(1S)-1-(diméthylamino)éthyl]phényle (1:1) |
| RivastigMine L-Tartrate |
| Rivastigmine Tartrate Salt |
| N-Ethyl-N-methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Rivastigmine |
| (2R,3R)-2,3-Dihydroxysuccinic acid - 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate (1:1) |
| (S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (2R,3R)-2,3-dihydroxysuccinate |
| Rivastigmine Tartrate |
| 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate 2,3-dihydroxybutanedioate (salt) |
| (2R,3R)-2,3-Dihydroxybutandisäure--3-[(1S)-1-(dimethylamino)ethyl]phenyl-ethyl(methyl)carbamat(1:1) |
| 3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-methylcarbamate L-Tartrate |
| Rivastigmine hydrogen tartrate |
| Rivastigmine (tartrate) |