lecimibide
Modify Date: 2024-01-02 17:46:58
lecimibide structure
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Common Name | lecimibide | ||
|---|---|---|---|---|
| CAS Number | 130804-35-2 | Molecular Weight | 590.76900 | |
| Density | 1.21g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C34H40F2N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of lecimibideLecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2]. |
| Name | 3-(2,4-difluorophenyl)-1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl]-1-heptylurea |
|---|---|
| Synonym | More Synonyms |
| Description | Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Lecimibide (DuP 128)(10 μM, 24 h)可以抑制 HepG2 细胞 85% 的细胞酯化反应[1]。 |
| In Vivo | Lecimibide (DuP 128)(i.v., 2.2 mg/kg/day) 在饲养高脂肪和胆固醇的猪中，显著降低了总血浆甘油三酯和极低密度脂蛋白(VLDL)甘油三酯浓度，分别降低了 36% 和 31%。而对总胆固醇、VLDL 胆固醇、LDL 胆固醇、HDL 胆固醇或 LDL apoB 浓度没有显著影响[2]。 |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Molecular Formula | C34H40F2N4OS |
| Molecular Weight | 590.76900 |
| Exact Mass | 590.28900 |
| PSA | 89.81000 |
| LogP | 9.80240 |
| Index of Refraction | 1.613 |
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~58%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
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~%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
|
~%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
|
~%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
|
~%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
|
~%
lecimibide CAS#:130804-35-2 |
| Literature: Higley; Wilde; Maduskuie; Johnson; Pennev; Billheimer; Robinson; Gillies; Wexler Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3511 - 3522 |
![N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-1-heptanamine structure](https://www.chemsrc.com/caspic/128/136445-76-6.png)
| N'-(2,4-difluorophenyl)-N-[5-(4,5-diphenyl-1H-imidazol-2-ylthio)pentyl]-N-heptylurea |
| urea,n'-(2,4-difluorophenyl)-n-[5-[(4,5-diphenyl-1h-imidazol-2-yl)thio]pentyl]-n-heptyl |
| Lecimibide |
| Lecimibide (USAN) |