Kaurane-3,16,17-triol
Modify Date: 2024-02-01 23:02:50
Kaurane-3,16,17-triol structure
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Common Name | Kaurane-3,16,17-triol | ||
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| CAS Number | 130855-22-0 | Molecular Weight | 322.48 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 461.6±40.0 °C at 760 mmHg | |
| Molecular Formula | C20H34O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 207.1±21.9 °C | |
Use of Kaurane-3,16,17-triolent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1]. |
| Name | (3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol |
|---|---|
| Synonym | More Synonyms |
| Description | ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1]. |
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| Related Catalog | |
| In Vitro | ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) 抑制 HepG2 和 HCT116 细胞增殖，IC50 值分别为 45.5 和 29.84 µM[1]。 ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) 抑制 HCT116 细胞集落形成[1]。 ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) 诱导人结肠癌细胞周期阻滞[1]。 ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) 诱导人结肠癌细胞凋亡[1]。 Cell Viability Assay[1] Cell Line: HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells Concentration: 0-100 μM Incubation Time: 24 h Result: Showed inhibitory effects with IC50s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively. Cell Cycle Analysis[1] Cell Line: HCT116 Concentration: 30 and 40 µM Incubation Time: 48 h Result: Significantly increased the cell population at the G0/G1 phase in a dosedependent manner. Apoptosis Analysis[1] Cell Line: HCT116 Concentration: 30 and 40 µM Incubation Time: 72 h Result: Increased the percentage of both early and late apoptotic cells. Western Blot Analysis[1] Cell Line: HCT116 Concentration: 30 μM Incubation Time: 72 h Result: Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 461.6±40.0 °C at 760 mmHg |
| Molecular Formula | C20H34O3 |
| Molecular Weight | 322.48 |
| Flash Point | 207.1±21.9 °C |
| Exact Mass | 322.250793 |
| PSA | 60.69000 |
| LogP | 3.34 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.567 |
| Hazard Codes | Xi |
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| Isoaureosid-aglykon |
| ent-kaurane-17,19-diol |
| (3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol |
| Kauran-17,19-diol |
| Kaurane-16,17-diol |
| Kaurane-3,16,17-triol |
| Ent-kauran-16,17-diol |