BioBioPha
China
Product Name: Kaurane-3,16,17-triol
Price: ￥4650.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ENT-KAURANE-3,16,17-TRIOL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

130855-22-0

130855-22-0 structure

130855-22-0 structure

Name: Kaurane-3,16,17-triol
Chemical Name: (3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol
CAS Number: 130855-22-0
Molecular Formula: C₂₀H₃₄O₃
Molecular Weight: 322.48
Catalog: Natural product Moss
Create Date: 2017-04-04 07:14:47
Modify Date: 2024-02-01 23:02:50
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1].

Name	(3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol
Synonyms	Isoaureosid-aglykon ent-kaurane-17,19-diol (3α,5β,8α,9β,10α,13α)-Kaurane-3,16,17-triol Kauran-17,19-diol Kaurane-16,17-diol Kaurane-3,16,17-triol Ent-kauran-16,17-diol

Description	ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) 抑制 HepG2 和 HCT116 细胞增殖，IC50 值分别为 45.5 和 29.84 µM[1]。 ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) 抑制 HCT116 细胞集落形成[1]。 ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) 诱导人结肠癌细胞周期阻滞[1]。 ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) 诱导人结肠癌细胞凋亡[1]。 Cell Viability Assay[1] Cell Line: HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells Concentration: 0-100 μM Incubation Time: 24 h Result: Showed inhibitory effects with IC50s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively. Cell Cycle Analysis[1] Cell Line: HCT116 Concentration: 30 and 40 µM Incubation Time: 48 h Result: Significantly increased the cell population at the G0/G1 phase in a dosedependent manner. Apoptosis Analysis[1] Cell Line: HCT116 Concentration: 30 and 40 µM Incubation Time: 72 h Result: Increased the percentage of both early and late apoptotic cells. Western Blot Analysis[1] Cell Line: HCT116 Concentration: 30 μM Incubation Time: 72 h Result: Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2.
References	[1]. Chen X, et al. Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells. Food Funct. 2017 Mar 22;8(3):1052-1060.

Density	1.2±0.1 g/cm3
Boiling Point	461.6±40.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₄O₃
Molecular Weight	322.48
Flash Point	207.1±21.9 °C
Exact Mass	322.250793
PSA	60.69000
LogP	3.34
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.567

Hazard Codes	Xi