H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt
Modify Date: 2024-01-02 16:33:53
H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt structure
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Common Name | H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 131167-89-0 | Molecular Weight | 528.685 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 856.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C25H48N6O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 471.9±34.3 °C | |
Use of H-Ile-Lys-Val-Ala-Val-OH trifluoroacetate saltH-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. |
| Name | Laminin-1 peptide |
|---|---|
| Synonym | More Synonyms |
| Description | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. |
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| Related Catalog | |
| Target |
ERK1 ERK2 Akt |
| In Vitro | H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 诱导骨髓间充质干细胞(BMMSC)增殖和增殖细胞核抗原(PCNA)合成[2]。 H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) 诱导 BMMSC 细胞周期，使细胞从 G0/G1 进入 S 期并阻止它们进入 G2/M 期[2]。 H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) 通过增强 BMMSCs 中 ERK1/2 和 Akt 的磷酸化水平激活 MAPK/ERK 和 PI3K/Akt 信号通路[2]。 Cell Proliferation Assay[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner. Cell Cycle Analysis[2] Cell Line: BMMSC Concentration: 5 mM Incubation Time: 24 h Result: Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation. Western Blot Analysis[2] Cell Line: BMMSC Concentration: 0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM Incubation Time: 0, 12, 24, 36, 48 h Result: Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 856.6±65.0 °C at 760 mmHg |
| Molecular Formula | C25H48N6O6 |
| Molecular Weight | 528.685 |
| Flash Point | 471.9±34.3 °C |
| Exact Mass | 528.363525 |
| LogP | 1.27 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.511 |
| L-Isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine |
| L-Valine, L-isoleucyl-L-lysyl-L-valyl-L-alanyl- |
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: isoleucyl-lysyl-valyl-alanyl-valine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Laminin α-1 Chain (2099-2103) (human)
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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