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China
Product Name: Pheniramine maleate
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China
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DC Chemicals Limited
China
Product Name: Pheniramine Maleate
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Pheniramine Maleate
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pheniramine maleate
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132-20-7

132-20-7 structure

Name: Pheniramine maleate
Chemical Name: Pheniramine Maleate
CAS Number: 132-20-7
Molecular Formula: C₂₀H₂₄N₂O₄
Molecular Weight: 356.416
Catalog: API Antiallergic Antihistamine
Create Date: 2018-08-31 15:42:30
Modify Date: 2024-01-02 16:27:08
Pheniramine Maleate ia an antihistamine and vasoconstrictor.

Name	Pheniramine Maleate
Synonyms	(2Z)-But-2-endisäure--N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amin(1:1) Pheniramine maleate 1-(N,N-Dimethylamino)-3-(phenyl-3-a-pyridyl)propane Maleate N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1) EINECS 205-051-4 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylamine Maleate N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate (Z)-but-2-enedioic acid,N,N-dimethyl-3-phenyl-3-pyridin-2-ylpropan-1-amine Pheniramine maleate salt 2-Pyridinepropanamine, N,N-dimethyl-γ-phenyl-, (2Z)-2-butenedioate (1:1) N,N-Dimethyl-3-phenyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1) acide (2Z)-but-2-ènedioïque - N,N-diméthyl-3-phényl-3-pyridin-2-ylpropan-1-amine (1:1) UNII:NYW905655B Naphcon A MFCD00079250

Description	Pheniramine Maleate ia an antihistamine and vasoconstrictor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology

Boiling Point	348.3ºC at 760 mmHg
Melting Point	104-108°C
Molecular Formula	C₂₀H₂₄N₂O₄
Molecular Weight	356.416
Flash Point	164.5ºC
Exact Mass	356.173615
PSA	90.73000
LogP	2.87700
Vapour Pressure	5.07E-05mmHg at 25°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	>=1 g/100 mL at 24 ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT0175000

CAS REGISTRY NUMBER :: 132-20-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C16-H20-N2.C4-H4-O4

MOLECULAR WEIGHT :: 356.46

WISWESSER LINE NOTATION :: T6NJ BYR&2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 520 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 268 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 111 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 1120 ug/kg

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,516,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83158 No. of Facilities: 1580 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6126 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83158 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 494 (estimated) No. of Female Employees: 206 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT0175000

132-20-7	93554-83-7
980-71-2	113-92-8
2391-03-9	2438-32-6
18453-10-6	22630-25-7
23052-94-0	76095-56-2
1158522-08-7	933704-88-2
940364-43-2	134104-43-1
131615-57-1	352211-51-9
6906-52-1	930439-75-1
1018584-77-4	1189701-67-4