Chlorpheniramine

Modify Date: 2025-08-20 11:25:13

Chlorpheniramine Structure
Chlorpheniramine structure
Common Name Chlorpheniramine
CAS Number 132-22-9 Molecular Weight 274.78800
Density N/A Boiling Point N/A
Molecular Formula C16H19ClN2 Melting Point 25 °C (lit.)
MSDS N/A Flash Point N/A

 Use of Chlorpheniramine


Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases[1]. [2]. .

 Names

Name chlorphenamine
Synonym More Synonyms

 Chlorpheniramine Biological Activity

Description Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases[1]. [2]. .
Related Catalog
Target

IC50: 43μM in BV2 microglial cells

In Vitro Chlorpheniramine has an inhibitory effects with an value of IC50 is 43μM on proton currents in BV2 microglial cells[1]. . Cell Viability Assay Cell Line: Murine microglial BV2 cells[1]. Concentration: 100 μM Incubation Time: 5 min Result: Inhibited proton currents with moderate potency.
In Vivo Chloropheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) enhances white blood cells in the peripheral blood[2]. . Animal Model: Sprague-Dawley (SD) rats[2]. Dosage: 50, 100 and 200 μg/kg Administration: Chlorpheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) Result: Enhanced white blood cells in the peripheral blood, mostly due to the increases of B cells and monocytes, but not T cells and NK cells.
References

[1]. Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.

[2]. Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35(12):2183-9.

 Chemical & Physical Properties

Melting Point 25 °C (lit.)
Molecular Formula C16H19ClN2
Molecular Weight 274.78800
Exact Mass 274.12400
PSA 16.13000
LogP 3.81860

 Synthetic Route

 Synonyms

(S)-[3-(4-chloro-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amine
D-Chlorpheniramine
Isomerine
Phendextro
Dexclorfeniramina
Polaramin
Chlor-Trimeton
Fortamine
(+)-Chlorpheniramine
DEXCHLORPHENIRAMINE
[3H]-Chlorpheniramine
chloropheniramine
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Destral
(S)-[3-(4-Chlor-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amin
Trenelone
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