Ropivacaine hydrochloride

Modify Date: 2024-01-02 11:00:54

Ropivacaine hydrochloride Structure
Ropivacaine hydrochloride structure
 Common Name Ropivacaine hydrochloride
CAS Number 132112-35-7 Molecular Weight 328.88
Density 1.0±0.1 g/cm3 Boiling Point 410.2±45.0 °C at 760 mmHg
Molecular Formula C17H29ClN2O2 Melting Point 267-269ºC
MSDS Chinese USA Flash Point 201.9±28.7 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Ropivacaine hydrochloride


Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2].

 Names

Name (S)-ropivacaine hydrochloride hydrate
Synonym More Synonyms

 Ropivacaine hydrochloride Biological Activity

Description Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.Target: Sodium ChannelRopivacaine is a new long-acting local anesthetic, with vasoconstrictive properties. Ropivacaine given epidurally provided adequate sensory anesthesia and motor block for transurethral surgery. Addition of epinephrine did not provide any significant prolongation of the sensory or motor block, nor any influence upon the sympathetic block [1]. Ropivacaine was metabolized to 2',6'-pipecoloxylidide (PPX), 3'-hydroxyropivacaine (3'-OH Rop), and 4'-hydroxyropivacaine (4'-OH Rop) by hepatic microsomes from human and rat. Ropivacaine N-dealkylation and 3'-hydroxylation activities correlated well with the level of CYP3A4 and 1A2 in human hepatic microsomes, respectively [2].
Related Catalog
References

[1]. Cederholm, I., S. Anskar, and M. Bengtsson, Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth, 1994. 19(1): p. 18-33.

[2]. Oda, Y., et al., Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology, 1995. 82(1): p. 214-20.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 410.2±45.0 °C at 760 mmHg
Melting Point 267-269ºC
Molecular Formula C17H29ClN2O2
Molecular Weight 328.88
Flash Point 201.9±28.7 °C
PSA 41.57000
LogP 3.11
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.552
Storage condition Refrigerator

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338 + P310
Hazard Codes T: Toxic;
Risk Phrases R26/27/28
Safety Phrases 22-36/37/39-45
RIDADR UN 2811 6.1 / PGIII
HS Code 2933399090

 Synthetic Route

Ropivacaine structure

Ropivacaine

CAS#:84057-95-4

~82%

Ropivacaine hydrochloride Structure

Ropivacaine hyd...

CAS#:132112-35-7

Literature: Navinta LLC Patent: US2006/276654 A1, 2006 ; Location in patent: Page/Page column 5 ;
Ropivacaine Hydrochloride structure

Ropivacaine Hyd...

CAS#:98717-15-8

~%

Ropivacaine hydrochloride Structure

Ropivacaine hyd...

CAS#:132112-35-7

Literature: US2006/276654 A1, ; Page/Page column 5 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(S)-ROPIVACAINE HCL
(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide
(S)-ROPIVACAINE HYDROCHLORIDE
(S)ROPIVACAINE HYDROCHLORIDE
(S)-ROPIVACAINEHYDROCHLORIDE
UNII-V910P86109
(-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
Ropivacaine
Ropivacaine hydrochloride Monohydrate
(S)ROPIVACAINE HY DROCHLORIDE
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-, hydrochloride, hydrate (1:1:1)
S-ROPIVACAINE HCL
Ropivacaine (hydrochloride Monohydrate)
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide
(+-)-ropivacaine hydrochloride
(S)-ROPIVACAINEHCL
(S)-(-)-1-propyl-2',6'-pipecoloxylidide
S-ROPIVACAINEHCL
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-
Ropivacainehydrochloride
Ropivacaine hydrochloride
(S)-(-)-1-propyl-2',6'-pipecoloxylidine hydrochloride monohydrate
l-N-n-Propylpipecolic acid-2,6-xylidide
(-)-1-Propyl-2',6'-pipecoloxylidide
UNII-7IO5LYA57N
(S)-ropivacaine hydrochloride hydrate
(S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide
ropivacaine hydrochloride hydrate
Ropivacaine HCl.H2O
Ropivacaine HCl
S-ROPIVACAINE HYDROCHLORIDE
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride hydrate
(2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride hydrate
MFCD02102164
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Related Compounds: More...
Ropivacaine Hydrochloride
98717-15-8
Ropivacaine hydrochloride
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