AChE/BChE/BACE-1-IN-1

Modify Date: 2024-01-09 20:31:00

AChE/BChE/BACE-1-IN-1 structure	Common Name	AChE/BChE/BACE-1-IN-1
	CAS Number	1321361-13-0	Molecular Weight	350.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₁F₃N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AChE/BChE/BACE-1-IN-1

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].

Name	AChE/BChE/BACE-1-IN-1

Description	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 0.058 μM (hAChE), 0.082 μM (hBChE), 0.115 μM (hBACE-1)[1]
In Vivo	AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].
References	[1]. Choubey PK, et al. Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease. Bioorg Med Chem. 2020 Nov 15;28(22):115721.

Molecular Formula	C₁₉H₂₁F₃N₂O
Molecular Weight	350.38

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AChE/BChE/BACE-1-IN-1

Use of AChE/BChE/BACE-1-IN-1

Names

AChE/BChE/BACE-1-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.