SR-31747
Modify Date: 2024-01-10 19:13:56
SR-31747 structure
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Common Name | SR-31747 | ||
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| CAS Number | 132173-07-0 | Molecular Weight | 396.43700 | |
| Density | N/A | Boiling Point | 479.9ºC at 760 mmHg | |
| Molecular Formula | C23H35Cl2N | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 244.1ºC | |
Use of SR-31747SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2]. |
| Name | N-[(Z)-3-(3-chloro-4-cyclohexylphenyl)prop-2-enyl]-N-ethylcyclohexanamine,hydrochloride |
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| Synonym | More Synonyms |
| Description | SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2]. |
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| Related Catalog | |
| Target |
Sigma ligand[1] |
| In Vitro | SR-31747 blocks the proliferation of lymphocytes at a concentration of 10 nM. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner[2]. |
| In Vivo | In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1]. |
| References |
| Boiling Point | 479.9ºC at 760 mmHg |
|---|---|
| Molecular Formula | C23H35Cl2N |
| Molecular Weight | 396.43700 |
| Flash Point | 244.1ºC |
| Exact Mass | 395.21500 |
| PSA | 3.24000 |
| LogP | 7.85750 |
| Vapour Pressure | 2.26E-09mmHg at 25°C |
| Storage condition | 2-8°C |
| HS Code | 2921499090 |
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| HS Code | 2921499090 |
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| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
| (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride |
| (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)-2-propenyl)-N-ethylcyclohexanamine hydrochloride |