Closantel-13C6

Modify Date: 2024-01-09 13:16:04

Closantel-13C6 structure	Common Name	Closantel-13C6
	CAS Number	1325559-20-3	Molecular Weight	669.030
	Density	1.9±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₆₁₃C₆H₁₄Cl₂I₂N₂O₂	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Closantel-13C6

Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

Name	Closantel-13C6
Synonym	More Synonyms

Description	Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [3]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72.

Density	1.9±0.1 g/cm3
Molecular Formula	C₁₆₁₃C₆H₁₄Cl₂I₂N₂O₂
Molecular Weight	669.030
Exact Mass	667.872253
Index of Refraction	1.736

Hazard Codes	Xn,N
Risk Phrases	22-50
Safety Phrases	61

MFCD20036275

N-{5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide-13C6

Closantel-(benzoyl ring-13C6)

N-{5-Chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodo(13C6)benzamide

Benzamide-1,2,3,4,5,6-13C6, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-

Closantel-13C6

Use of Closantel-13C6

Names

Closantel-13C6 Biological Activity

Chemical & Physical Properties

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Synonyms