3-(3-Phenoxybenzyl)amino-β-carboline

Modify Date: 2023-01-15 17:12:17

3-(3-Phenoxybenzyl)amino-β-carboline structure	Common Name	3-(3-Phenoxybenzyl)amino-β-carboline
	CAS Number	1327080-54-5	Molecular Weight	365.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₉N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3-(3-Phenoxybenzyl)amino-β-carboline

3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].

Name	3-(3-Phenoxybenzyl)amino-β-carboline

Description	3-(3-Phenoxybenzyl)amino-β-carboline is a potent tubulin inhibitor. 3-(3-Phenoxybenzyl)amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3-(3-Phenoxybenzyl)amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3-(3-Phenoxybenzyl)amino-β-carboline exhibits anticancer activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	3-(3-Phenoxybenzyl)amino-β-carboline specifically denatures tubulin, making it prone to aggregation that predisposes it to ubiquitinylation and then degradation[1].
References	[1]. Yang J, et al. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J Med Chem. 2022 Jun 28.

Molecular Formula	C₂₄H₁₉N₃O
Molecular Weight	365.43

3-(3-Phenoxybenzyl)amino-β-carboline

Use of 3-(3-Phenoxybenzyl)amino-β-carboline

Names

3-(3-Phenoxybenzyl)amino-β-carboline Biological Activity

Chemical & Physical Properties