vinaxanthone

Modify Date: 2025-08-25 13:58:18

vinaxanthone structure	Common Name	vinaxanthone
	CAS Number	133293-89-7	Molecular Weight	576.41800
	Density	1.772g/cm3	Boiling Point	1064.4ºC at 760mmHg
	Molecular Formula	C₂₈H₁₆O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	357.6ºC

Use of vinaxanthone

Vinaxanthone (SM-345431) is a potent and selective semaphorin3A inhibitor. Vinaxanthone exhibits semaphorin3A inhibiting activity with an IC50 of 0.1-0.2 μM[1]. Vinaxanthone shows selective inhibitory activity against phospholipase C (PLC) from rat brain, mutine colon 26 Adenocarcinoma and murine fibroblasts NIH3T3 with IC50s being 5.4, 9.3 and 44 μM, respectively[2].

Name	5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-yl)-2,3-dihydroxy-9-oxoxanthene-1-carboxylic acid
Synonym	More Synonyms

Description	Vinaxanthone (SM-345431) is a potent and selective semaphorin3A inhibitor. Vinaxanthone exhibits semaphorin3A inhibiting activity with an IC50 of 0.1-0.2 μM[1]. Vinaxanthone shows selective inhibitory activity against phospholipase C (PLC) from rat brain, mutine colon 26 Adenocarcinoma and murine fibroblasts NIH3T3 with IC50s being 5.4, 9.3 and 44 μM, respectively[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
References	[1]. Masahiro Aoki, et al. Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum. Tetrahedron Letters. 1991, 32 (36):4737-4740. [2]. Liang Zhang, et al. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7:14.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

References

[1]. Masahiro Aoki, et al. Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum. Tetrahedron Letters. 1991, 32 (36):4737-4740.

[2]. Liang Zhang, et al. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7:14.

Density	1.772g/cm3
Boiling Point	1064.4ºC at 760mmHg
Molecular Formula	C₂₈H₁₆O₁₄
Molecular Weight	576.41800
Flash Point	357.6ºC
Exact Mass	576.05400
PSA	250.08000
LogP	3.34360
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.768

Vinaxanthone

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China
Product Name: vinaxanthone
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: vinaxanthone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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vinaxanthone

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