vinaxanthone

• 常用名: vinaxanthone
• 英文名: vinaxanthone
• CAS号: 133293-89-7
• 分子量: 576.41800
• 密度: 1.772g/cm3
• 沸点: 1064.4ºC at 760mmHg
• 分子式: C₂₈H₁₆O₁₄
• 熔点: N/A
• 闪点: 357.6ºC

vinaxanthone用途

长春花酮(SM-345431)是一种有效且选择性的信号素3A抑制剂。长春花酮具有信号素3A抑制活性,IC50为0.1-0.2μM[1]。长春花酮对来自大鼠脑、多发性结肠腺癌和小鼠成纤维细胞NIH3T3的磷脂酶C(PLC)具有选择性抑制活性,IC50分别为5.4、9.3和44μM[2]。

vinaxanthone名称

• 英文名: 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-yl)-2,3-dihydroxy-9-oxoxanthene-1-carboxylic acid

vinaxanthone生物活性

• 描述: 长春花酮(SM-345431)是一种有效且选择性的信号素3A抑制剂。长春花酮具有信号素3A抑制活性,IC50为0.1-0.2μM[1]。长春花酮对来自大鼠脑、多发性结肠腺癌和小鼠成纤维细胞NIH3T3的磷脂酶C(PLC)具有选择性抑制活性,IC50分别为5.4、9.3和44μM[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
• 参考文献:

  [1]. Masahiro Aoki, et al. Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum. Tetrahedron Letters. 1991, 32 (36):4737-4740.

  [2]. Liang Zhang, et al. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7:14.

vinaxanthone物理化学性质

• 密度: 1.772g/cm3
• 沸点: 1064.4ºC at 760mmHg
• 分子式: C₂₈H₁₆O₁₄
• 分子量: 576.41800
• 闪点: 357.6ºC
• 精确质量: 576.05400
• PSA: 250.08000
• LogP: 3.34360
• InChIKey: MEYYEMQDVMMNNR-UHFFFAOYSA-N
• SMILES: CC(=O)c1cc2c(=O)c3c(C(=O)O)c(O)c(O)cc3oc2c(C(C)=O)c1-c1coc2cc(O)c(O)c(C(=O)O)c2c1=O
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.768

vinaxanthone靶点实验

查看更多实验

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

实验名称：USP30 deubiquitinase inhibition: Dose-response Confirmation 来源：24642 靶标：ubiquitin specific peptidase 30 External Id：USP30 FAST DUB HTS Confirmation

实验名称：Antifungal activity against Saccharomyces cerevisiae after 18 to 24 hrs by disk diffu... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL984360

实验名称：USP17 deubiquitinase inhibition: Dose-response Confirmation 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Confirmation

实验名称：Antibacterial activity against Escherichia coli by disk diffusion test 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL984359

实验名称：Antitumor activity against Agrobacterium tumefaciens-induced 10 ppm crown gall tumor ... 来源：ChEMBL 靶标：Agrobacterium tumefaciens External Id：CHEMBL984362

实验名称：USP28 deubiquitinase inhibition: Dose-response Confirmation 来源：24642 靶标：ubiquitin specific peptidase 28 External Id：USP28 FAST DUB HTS Confirmation

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vinaxanthone英文别名

• Vinaxanthone
• 411F