(E/Z)-Locostatin

Modify Date: 2024-01-04 07:07:37

(E/Z)-Locostatin structure	Common Name	(E/Z)-Locostatin
	CAS Number	133812-16-5	Molecular Weight	245.27400
	Density	1.205g/cm3	Boiling Point	351ºC at 760mmHg
	Molecular Formula	C₁₄H₁₅NO₃	Melting Point	84-88ºC(lit.)
	MSDS	N/A	Flash Point	166.1ºC

Use of (E/Z)-Locostatin

(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].

Name	(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
Synonym	More Synonyms

Description	(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	RKIP[3]
References	[1]. Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. [2]. Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. [3]. Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998.

Density	1.205g/cm3
Boiling Point	351ºC at 760mmHg
Melting Point	84-88ºC(lit.)
Molecular Formula	C₁₄H₁₅NO₃
Molecular Weight	245.27400
Flash Point	166.1ºC
Exact Mass	245.10500
PSA	46.61000
LogP	2.09050
Vapour Pressure	4.22E-05mmHg at 25°C
Index of Refraction	1.57

Hazard Codes	Xn

MFCD00278769

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (S)-4-BENZYL-3-(BUT-2-ENOYL)OXAZOLIDIN-2-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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