133812-16-5

133812-16-5 structure

Name: (E/Z)-Locostatin
Chemical Name: (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
CAS Number: 133812-16-5
Molecular Formula: C₁₄H₁₅NO₃
Molecular Weight: 245.27400
Catalog: Research Areas Cancer
Create Date: 2018-12-16 11:16:28
Modify Date: 2024-01-04 07:07:37
(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].

Name	(S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one
Synonyms	MFCD00278769

Description	(E/Z)-Locostatin ((E/Z)-UIC-1005) is a racemic of Locostatin. Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	RKIP[3]
References	[1]. Beshir AB, et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58. [2]. Mc Henry KT, et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11. [3]. Lin X, et al. Inhibition of RKIP aggravates thioacetamide-induced acute liver failure in mice. Exp Ther Med. 2018 Oct;16(4):2992-2998.

Hazard Codes	Xn