8-Bromo-2'-deoxyguanosine

Modify Date: 2024-01-05 23:18:38

8-Bromo-2'-deoxyguanosine Structure
8-Bromo-2'-deoxyguanosine structure
Common Name 8-Bromo-2'-deoxyguanosine
CAS Number 13389-03-2 Molecular Weight 346.14
Density 2.5±0.1 g/cm3 Boiling Point 727ºC at 760 mmHg
Molecular Formula C10H12BrN5O4 Melting Point >250ºC dec.
MSDS N/A Flash Point 393.5ºC

 Use of 8-Bromo-2'-deoxyguanosine


8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 8-Bromo-2'-deoxyguanosine
Synonym More Synonyms

 8-Bromo-2'-deoxyguanosine Biological Activity

Description 8-Bromo-2'-deoxyguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.5±0.1 g/cm3
Boiling Point 727ºC at 760 mmHg
Melting Point >250ºC dec.
Molecular Formula C10H12BrN5O4
Molecular Weight 346.14
Flash Point 393.5ºC
Exact Mass 345.007263
PSA 139.28000
LogP -0.02
Appearance of Characters Powder | White to Off-white
Vapour Pressure 3.46E-22mmHg at 25°C
Index of Refraction 1.941
Storage condition -20°C Freezer
Water Solubility Soluble in dimethyl sulfoxide, warm water and dimethyl formamide.

 Safety Information

Hazard Codes T+

 Synthetic Route

~92%

8-Bromo-2'-deoxyguanosine Structure

8-Bromo-2'-deox...

CAS#:13389-03-2

Literature: Muenzel, Martin; Szeibert, Claudia; Glas, Andreas F.; Globisch, Daniel; Carell, Thomas Journal of the American Chemical Society, 2011 , vol. 133, # 14 p. 5186 - 5189

~39%

8-Bromo-2'-deoxyguanosine Structure

8-Bromo-2'-deox...

CAS#:13389-03-2

Literature: Gannett; Sura Synthetic Communications, 1993 , vol. 23, # 11 p. 1611 - 1615

~17%

8-Bromo-2'-deoxyguanosine Structure

8-Bromo-2'-deox...

CAS#:13389-03-2

Literature: Gannett; Sura Synthetic Communications, 1993 , vol. 23, # 11 p. 1611 - 1615

 Synonyms

2'-Deoxy-8-bromoguanosine
C8-bromo-2'-deoxyguanosine
Guanosine, 8-bromo-2'-deoxy-
8-Br-dG
8-bromo-2'-deoxyuanosine
8-Bromo-2'-deoxyguanosine
8-Bromo-2'-deoxy-D-guanosine
2-Amino-8-bromo-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
8-bromo2'-deoxyguansine