Methyclothiazide

Modify Date: 2026-07-03 07:19:40

Methyclothiazide structure	Common Name	Methyclothiazide
	CAS Number	135-07-9	Molecular Weight	360.237
	Density	1.6±0.1 g/cm3	Boiling Point	597.9±60.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₁Cl₂N₃O₄S₂	Melting Point	223-225ºC
	MSDS	N/A	Flash Point	315.4±32.9 °C

Use of Methyclothiazide

Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro[1][2][3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Research Areas >> Metabolic Disease
Target	IC50: voltage-dependent Ca-channel (VDCC)
In Vitro	Methyclothiazide (0-100 μM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from SHR, and the maximal vasoconstrictive effect of Norepinephrine (HY-13715) and arginine vasopressin (AVP) is decreased by 59% and 32.3 %, respectively[1]. Methyclothiazide (0-100 μM) induces inhibitory effect on the contractile response to Norepinephrine (HY-13715) is abolished by N-nitro-L-arginine (NOLA) but not indomethacin[1]. Methyclothiazide (100 μM) affects the vascular responses to extracellular Ca2+ under high-K+ depolarizing conditions. It can reduce Ca2+ contracture in a high-K+, Ca2+-free solution. The maximal contracture is reduced by 90.4%[1].
References	[1]. Colas, B., et al., Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol, 2000. 408(1): p. 63-7. [2]. Colas, B., et al., Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol, 2000. 14(4): p. 363-8. [3]. Sasaki, S. and R.D. Bunag, Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J Cardiovasc Pharmacol, 1983. 5(3): p. 378-83.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.6±0.1 g/cm3
Boiling Point	597.9±60.0 °C at 760 mmHg
Melting Point	223-225ºC
Molecular Formula	C₉H₁₁Cl₂N₃O₄S₂
Molecular Weight	360.237
Flash Point	315.4±32.9 °C
Exact Mass	358.956787
PSA	126.33000
LogP	1.76
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.606
InChIKey	CESYKOGBSMNBPD-UHFFFAOYSA-N
SMILES	CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O
Storage condition	-20℃

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK8575000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-, 1,1-dioxide

CAS REGISTRY NUMBER :: 135-07-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C9-H11-Cl2-N3-O4-S2

MOLECULAR WEIGHT :: 360.25

WISWESSER LINE NOTATION :: T66 BSWN EM DHJ C1 D1G HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 140 mg/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9137 No. of Facilities: 54 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 859 (estimated) No. of Female Employees: 574 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

RIDADR	NONH for all modes of transport

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

4-Amino-6-chlor...

CAS#:121-30-2

Methyclothiazide

CAS#:135-07-9

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Literature: Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135

$4-chloro-10-hydroxy-8,10-dioxo-10$l^{6}-thia-7,9-diazabicyclo[4.4.0]deca-2,4,6,10-tetraene-3-sulfonamide structure$

4-chloro-10-hyd...

CAS#:89813-56-9

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CAS#:135-07-9

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Literature: Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135

6-chloro-2-meth...

CAS#:89813-57-0

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Literature: Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135

Chloroacetaldehyde

CAS#:107-20-0

6-Amino-4-chlor...

CAS#:13659-98-8

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CAS#:135-07-9

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Literature: Journal of the American Chemical Society, , vol. 82, p. 1132 - 1135

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 3
CAS#:121-30-2 4-Amino-6-chlor... $4-chloro-10-hydroxy-8,10-dioxo-10$l^{6}-thia-7,9-diazabicyclo[4.4.0]deca-2,4,6,10-tetraene-3-sulfonamide Structure$ CAS#:89813-56-9 4-chloro-10-hyd... CAS#:107-20-0 Chloroacetaldehyde
DownStream 0

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Methycyclothiazide

6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-di-oxide

6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

methyl chlothiazide

EINECS 205-172-2

Enduronum

Enduron

UNII:L3H46UAC61

Aquatensen

Duretic

methylclothiazide

6-chloro-3-(chlorométhyl)-2-méthyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxyde

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

methychlothiazide

methyclothiazide

Aquaresen

Naturon

MFCD00242610

Methyclothiazid

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: LogP of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 1.76.

Q: What are the uses of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Main uses of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide: Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro[1][2][3].

Q: What is the English name of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: The English name of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide.

Q: What is the boiling point of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Boiling point of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 597.9±60.0 °C at 760 mmHg.

Q: What are the storage conditions for 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Storage conditions for 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide: -20℃.

Q: What is the SMILES notation of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: SMILES notation of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O.

Q: What is the InChIKey of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: InChIKey of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is CESYKOGBSMNBPD-UHFFFAOYSA-N.

Q: What are the upstream materials of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Related upstream materials(CAS) of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide: 121-30-2;89813-56-9;107-20-0.

Q: What is the polar surface area (PSA) of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Polar surface area (PSA) of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 126.33000.

Q: What is the molecular weight of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide?

A: Molecular weight of 6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 360.237.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

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