Bis-propargyl-PEG12

Modify Date: 2024-01-14 17:33:38

Bis-propargyl-PEG12 Structure
Bis-propargyl-PEG12 structure
Common Name Bis-propargyl-PEG12
CAS Number 1351373-50-6 Molecular Weight 622.742
Density 1.1±0.1 g/cm3 Boiling Point 623.4±50.0 °C at 760 mmHg
Molecular Formula C30H54O13 Melting Point N/A
MSDS N/A Flash Point 222.7±30.0 °C

 Use of Bis-propargyl-PEG12


Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bis-Propargyl-PEG13
Synonym More Synonyms

 Bis-propargyl-PEG12 Biological Activity

Description Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 623.4±50.0 °C at 760 mmHg
Molecular Formula C30H54O13
Molecular Weight 622.742
Flash Point 222.7±30.0 °C
Exact Mass 622.356445
LogP -3.28
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.467

 Synonyms

MFCD28334510
4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne
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