VT-464 (R enantiomer)

Modify Date: 2024-01-02 16:28:07

VT-464 (R enantiomer) structure	Common Name	VT-464 (R enantiomer)
	CAS Number	1375603-38-5	Molecular Weight	399.33900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₇F₄N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VT-464 (R enantiomer)

Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.

Name	1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol
Synonym	More Synonyms

Description	Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. [2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

Description

Seviteronel (VT-464) R enantiomer is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7.

[2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1