[Lys5,MeLeu9,Nle10] -NKA(4-10)

Modify Date: 2025-08-27 00:05:50

Use of [Lys5,MeLeu9,Nle10] -NKA(4-10)

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].

Name	[Lys5,MeLeu9,Nle10]-NKA(4-10)
Synonym	More Synonyms

Description	[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
References	[1]. G Chassaing, et al. Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides. 1991 Jun;19(2):91-5. [2]. M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352(1):103-9.

Description

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM[1].

Related Catalog

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

References

Molecular Formula	C₃₉H₆₅N₉O₉
Molecular Weight	803.98800
Exact Mass	803.49100
PSA	298.24000
LogP	3.47550
InChIKey	FIBMQAYBIOYAKI-HLYNNXGTSA-N
SMILES	CCCCC(NC(=O)C(CC(C)C)N(C)C(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCCN)NC(=O)C(N)CC(=O)O)C(C)C)C(N)=O
Storage condition	-20°C

L-Asp-L-Lys-L-Phe-L-Val-Gly-N-methyl-L-Leu-L-Nle-NH2

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