Mal-PFP ester

Modify Date: 2024-01-12 19:45:02

Mal-PFP ester Structure
Mal-PFP ester structure
Common Name Mal-PFP ester
CAS Number 138194-55-5 Molecular Weight 335.18
Density N/A Boiling Point N/A
Molecular Formula C13H6F5NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-PFP ester


Mal-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-PFP ester

 Mal-PFP ester Biological Activity

Description Mal-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C13H6F5NO4
Molecular Weight 335.18
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