Sardomozide dihydrochloride

Modify Date: 2024-01-12 17:39:59

Sardomozide dihydrochloride structure	Common Name	Sardomozide dihydrochloride
	CAS Number	138794-73-7	Molecular Weight	303.19
	Density	1.5±0.1 g/cm3	Boiling Point	490.6±55.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₆Cl₂N₆	Melting Point	N/A
	MSDS	N/A	Flash Point	250.5±31.5 °C

Use of Sardomozide dihydrochloride

Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.

Name	Sardomozide HCl
Synonym	More Synonyms

Description	Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 5 nM (SAMDC)[1]
In Vitro	Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control[1]. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells[2].
Cell Assay	The parent CHO cell line is chronically exposed to increasing levels of Sardomozide for at least eight passages beginning at 0.1 μM. Cell lines are serially exposed to increasing concentrations until a panel of sublines is obtained resistant to 1 (CHO/1). 3 (CHO/3), 10 (CHO/10), 30 (CHO/30), and 100 (CHO/100) μM Sardomozide for comparative studies[2].
References	[1]. Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7. [2]. Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58(17):3883-90.

Sardomozide

(1E)-1-[(Diaminomethylene)hydrazono]-4-indanecarboximidamide

1H-Indene-4-carboximidamide, 1-[2-(diaminomethylene)hydrazinylidene]-2,3-dihydro-, (1E)-

Sardomozide dihydrochloride

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