4-thiouridine

Modify Date: 2024-01-09 18:05:41

4-thiouridine Structure
4-thiouridine structure
Common Name 4-thiouridine
CAS Number 13957-31-8 Molecular Weight 260.267
Density 1.7±0.1 g/cm3 Boiling Point N/A
Molecular Formula C9H12N2O5S Melting Point 139-140℃ (ethanol )
MSDS Chinese USA Flash Point N/A

 Use of 4-thiouridine


4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].

 Names

Name 4-thiouridine
Synonym More Synonyms

 4-thiouridine Biological Activity

Description 4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].
Related Catalog
In Vitro 4-thiouridine (0-10 μM) labels and purifies nascent rRNA without significantly affecting rRNA synthesis[1]. 4-thiouridine (≥50 μM) strongly inhibits production and processing of rRNA[1].
References

[1]. Burger K, et al. 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 2013 Oct;10(10):1623-30.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Melting Point 139-140℃ (ethanol )
Molecular Formula C9H12N2O5S
Molecular Weight 260.267
Exact Mass 260.046692
PSA 139.80000
LogP -0.21
Index of Refraction 1.733
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes C
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

EINECS 237-735-3
2(1H)-Pyrimidinone, 3,4-dihydro-1-β-D-ribofuranosyl-4-thioxo-
4-Thio-uridin
4-Thio-D-uridine
MFCD00006538
4-thio-uridine
1-(β-D-Ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
Uridine,4-thio
thiouridine
4-SH-Ur
THIOURIDINE,4
4-thiouridine
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