NLG919
Modify Date: 2024-01-02 11:21:15
NLG919 structure
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Common Name | NLG919 | ||
|---|---|---|---|---|
| CAS Number | 1402836-58-1 | Molecular Weight | 282.380 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 524.6±33.0 °C at 760 mmHg | |
| Molecular Formula | C18H22N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 271.1±25.4 °C | |
Use of NLG919IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM. |
| Name | 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM. |
|---|---|
| Related Catalog | |
| Target |
IDO1:38 nM (IC50) |
| In Vitro | IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM). The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier[1]. |
| Cell Assay | IDO-IN-7 (NLG-919 analogue) and the selected fragments 8, 15, and 18 are tested in cellular assay for their ability to cross cell membrane and inhibit IDO1 catalytic activity. The cell line of murine mastocytoma P1.HTR stably transfected with murine IDO1 (P1.IDO1) is cultured for 16 hrs in the presence of each compound at the concentration of 30 mM. The ability of P1.IDO1 cells to convert LTrp contained in the culture medium at the concentration of 78.4 μM into L-Kyn is then assessed after 16 hrs of incubation[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 524.6±33.0 °C at 760 mmHg |
| Molecular Formula | C18H22N2O |
| Molecular Weight | 282.380 |
| Flash Point | 271.1±25.4 °C |
| Exact Mass | 282.173218 |
| PSA | 38.05000 |
| LogP | 3.28 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.676 |
| Storage condition | -20°C |
| Hazard Codes | Xi |
|---|
| 5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl- |
| 1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol |
| nlg919 |
| IDO-IN-7 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: NLG919
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: NLG919(GDC-0919)
- Price: $200.0/100mg $400.0/250mg $800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: NLG919(GDC-0919)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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Price: ￥452.4/5mg
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