Mutant IDH1-IN-4

Modify Date: 2024-02-06 13:20:00

Mutant IDH1-IN-4 Structure
Mutant IDH1-IN-4 structure
Common Name Mutant IDH1-IN-4
CAS Number 1416270-18-2 Molecular Weight 438.56246
Density N/A Boiling Point N/A
Molecular Formula C25H34N4O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mutant IDH1-IN-4


Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells[1].

 Names

Name (R)-8-cyclopropyl-6-(3-cyclopropyl-4-(3-methoxypropanoyl)piperazin-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile

 Mutant IDH1-IN-4 Biological Activity

Description Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells[1].
Related Catalog
Target

IC50: ≤ 0.5 μM (mutant IDH 1 in cells)[1].

References

[1]. US20170210749A1.

 Chemical & Physical Properties

Molecular Formula C25H34N4O3
Molecular Weight 438.56246
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Price: ¥9350/10 mM * 1 mL in DMSO

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