HDAC8-IN-1

Modify Date: 2024-02-07 15:48:58

HDAC8-IN-1 Structure
HDAC8-IN-1 structure
Common Name HDAC8-IN-1
CAS Number 1417997-93-3 Molecular Weight 345.39
Density N/A Boiling Point N/A
Molecular Formula C22H19NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HDAC8-IN-1


HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.

 Names

Name HDAC8-IN-1
Synonym More Synonyms

 HDAC8-IN-1 Biological Activity

Description HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM.
Related Catalog
Target

HDAC8:27.2 nM (IC50)

In Vitro HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d) shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5); HDAC8-IN-1 exhibits cytotoxicity against human lung CL1-5 cells without significant cytotoxicity for normal IMR-90 cells[1].
References

[1]. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.

 Chemical & Physical Properties

Molecular Formula C22H19NO3
Molecular Weight 345.39
Storage condition 2-8℃

 Synonyms

MFCD31619280
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