Piperazine Hexahydrate

Modify Date: 2024-01-05 00:56:19

Piperazine Hexahydrate Structure
Piperazine Hexahydrate structure
Common Name Piperazine Hexahydrate
CAS Number 142-63-2 Molecular Weight 194.22700
Density 1.92g/cm3 Boiling Point 145-156 °C(lit.)
Molecular Formula C4H22N2O6 Melting Point 42-44 °C(lit.)
MSDS Chinese USA Flash Point 190 °F
Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger

 Names

Name Piperazine Hexahydrate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.92g/cm3
Boiling Point 145-156 °C(lit.)
Melting Point 42-44 °C(lit.)
Molecular Formula C4H22N2O6
Molecular Weight 194.22700
Flash Point 190 °F
Exact Mass 194.14800
PSA 79.44000
Vapour Pressure 4.05mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM0850000
CHEMICAL NAME :
Piperazine, hexahydrate
CAS REGISTRY NUMBER :
142-63-2
LAST UPDATED :
199504
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H10-N2.6H2-O
MOLECULAR WEIGHT :
194.28
WISWESSER LINE NOTATION :
T6N DNTJ &QH 6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84706 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84706 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 127 (estimated) No. of Female Employees: 45 (estimated)

 Safety Information

Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger
Hazard Statements H314-H317-H334-H361fd
Precautionary Statements P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Hazard Codes C:Corrosive;
Risk Phrases R34;R42/43;R52/53
Safety Phrases S22-S26-S36/37/39-S45-S61
RIDADR UN 2579 8/PG 3
WGK Germany 1
RTECS TM0850000
Packaging Group III
Hazard Class 8
HS Code 2933599090

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

More Articles
Improved solvent formulations for efficient CO₂ absorption and low-temperature desorption.

ChemSusChem 5(9) , 1724-31, (2012)

This experimental study describes efficient CO₂ capture by 2-amino-2-methyl-1-propanol (AMP)/piperazine (PZ) in ethylene glycol monoethyl ether (EGMEE, 2-ethoxyethanol) containing approximately 15 wt ...

Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.

Mini Rev. Med. Chem. 12(12) , 1282-92, (2012)

In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-all...

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

J. Med. Chem. 56(6) , 2311-22, (2013)

On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth ...

 Synonyms

Diethylenediamine Hexahydrate
piperazine,hexahydrate
Piperazine hydrate
Piperazine hexahydrate
EINECS 203-808-3
MFCD00149389
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