Piperazine Hexahydrate

Modify Date: 2026-07-02 20:08:51

Piperazine Hexahydrate Structure
Piperazine Hexahydrate structure
Common Name Piperazine Hexahydrate
CAS Number 142-63-2 Molecular Weight 194.22700
Density 1.92g/cm3 Boiling Point 145-156 °C(lit.)
Molecular Formula C4H22N2O6 Melting Point 42-44 °C(lit.)
MSDS Chinese USA Flash Point 190 °F
Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name Piperazine Hexahydrate
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.92g/cm3
Boiling Point 145-156 °C(lit.)
Melting Point 42-44 °C(lit.)
Molecular Formula C4H22N2O6
Molecular Weight 194.22700
Flash Point 190 °F
Exact Mass 194.14800
PSA 79.44000
Vapour Pressure 4.05mmHg at 25°C
InChIKey AVRVZRUEXIEGMP-UHFFFAOYSA-N
SMILES C1CNCCN1.O.O.O.O.O.O

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM0850000
CHEMICAL NAME :
Piperazine, hexahydrate
CAS REGISTRY NUMBER :
142-63-2
LAST UPDATED :
199504
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C4-H10-N2.6H2-O
MOLECULAR WEIGHT :
194.28
WISWESSER LINE NOTATION :
T6N DNTJ &QH 6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
11200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84706 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84706 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 127 (estimated) No. of Female Employees: 45 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger
Hazard Statements H314-H317-H334-H361fd
Precautionary Statements P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338
Hazard Codes C:Corrosive;
Risk Phrases R34;R42/43;R52/53
Safety Phrases S22-S26-S36/37/39-S45-S61
RIDADR UN 2579 8/PG 3
WGK Germany 1
RTECS TM0850000
Packaging Group III
Hazard Class 8
HS Code 2933599090

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Improved solvent formulations for efficient CO₂ absorption and low-temperature desorption.

ChemSusChem 5(9) , 1724-31, (2012)

This experimental study describes efficient CO₂ capture by 2-amino-2-methyl-1-propanol (AMP)/piperazine (PZ) in ethylene glycol monoethyl ether (EGMEE, 2-ethoxyethanol) containing approximately 15 wt ...

Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.

Mini Rev. Med. Chem. 12(12) , 1282-92, (2012)

In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-all...

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

J. Med. Chem. 56(6) , 2311-22, (2013)

On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth ...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Diethylenediamine Hexahydrate
piperazine,hexahydrate
Piperazine hydrate
Piperazine hexahydrate
EINECS 203-808-3
MFCD00149389

 Piperazine Hexahydrate | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does Piperazine Hexahydrate have?
A: English synonyms of Piperazine Hexahydrate: Diethylenediamine Hexahydrate, piperazine,hexahydrate, Piperazine hydrate, Piperazine hexahydrate, EINECS 203-808-3, MFCD00149389.
Q: What is the CAS number of Piperazine Hexahydrate?
A: CAS number of Piperazine Hexahydrate is 142-63-2.
Q: What is the boiling point of Piperazine Hexahydrate?
A: Boiling point of Piperazine Hexahydrate is 145-156 °C(lit.).
Q: What is the safety information for Piperazine Hexahydrate?
A: Safety information for Piperazine Hexahydrate: S22-S26-S36/37/39-S45-S61.
Q: What is the InChIKey of Piperazine Hexahydrate?
A: InChIKey of Piperazine Hexahydrate is AVRVZRUEXIEGMP-UHFFFAOYSA-N.
Q: What is the molecular weight of Piperazine Hexahydrate?
A: Molecular weight of Piperazine Hexahydrate is 194.22700.
Q: What are the downstream products of Piperazine Hexahydrate?
A: Related downstream products(CAS) of Piperazine Hexahydrate: 40172-95-0;4164-39-0;31166-44-6;86620-81-7;5294-61-1;51940-44-4;70458-96-7;55436-41-4;5649-49-0;60703-69-7.
Q: What is the English name of Piperazine Hexahydrate?
A: The English name of Piperazine Hexahydrate is Piperazine Hexahydrate.
Q: What is the polar surface area (PSA) of Piperazine Hexahydrate?
A: Polar surface area (PSA) of Piperazine Hexahydrate is 79.44000.
Q: What is the molecular formula of Piperazine Hexahydrate?
A: Molecular formula of Piperazine Hexahydrate is C4H22N2O6.

 Piperazine Hexahydratefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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