SGK1 Inhibitor
Modify Date: 2024-01-11 19:04:16
SGK1 Inhibitor structure
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Common Name | SGK1 Inhibitor | ||
|---|---|---|---|---|
| CAS Number | 1426214-51-8 | Molecular Weight | 435.287 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 730.5±70.0 °C at 760 mmHg | |
| Molecular Formula | C17H12Cl2N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 395.6±35.7 °C | |
Use of SGK1 InhibitorSGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. |
| Name | SGK1 Inhibitor |
|---|---|
| Synonym | More Synonyms |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 730.5±70.0 °C at 760 mmHg |
| Molecular Formula | C17H12Cl2N6O2S |
| Molecular Weight | 435.287 |
| Flash Point | 395.6±35.7 °C |
| Exact Mass | 434.011963 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.750 |
| N-[4-(3-Amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide |
| MFCD31615459 |
| Benzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro- |
| SGK1 Inhibitor |