1426214-51-8
1426214-51-8 structure
- Name: SGK1 Inhibitor
- Chemical Name: SGK1 Inhibitor
- CAS Number: 1426214-51-8
- Molecular Formula: C17H12Cl2N6O2S
- Molecular Weight: 435.287
- Create Date: 2021-01-10 12:12:42
- Modify Date: 2024-01-11 19:04:16
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SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.
| Name | SGK1 Inhibitor |
|---|---|
| Synonyms |
N-[4-(3-Amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide
MFCD31615459 Benzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro- SGK1 Inhibitor |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 730.5±70.0 °C at 760 mmHg |
| Molecular Formula | C17H12Cl2N6O2S |
| Molecular Weight | 435.287 |
| Flash Point | 395.6±35.7 °C |
| Exact Mass | 434.011963 |
| LogP | 3.81 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.750 |