FGIN-1-27 structure
|
Common Name | FGIN-1-27 | ||
---|---|---|---|---|
CAS Number | 142720-24-9 | Molecular Weight | 436.60500 | |
Density | 1.073g/cm3 | Boiling Point | 608.3ºC at 760mmHg | |
Molecular Formula | C28H37FN2O | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 321.7ºC |
Use of FGIN-1-27FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions[1]. |
Name | 2-[2-(4-fluorophenyl)-1H-indol-3-yl]-N,N-dihexylacetamide |
---|---|
Synonym | More Synonyms |
Description | FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions[1]. |
---|---|
Related Catalog | |
References |
Density | 1.073g/cm3 |
---|---|
Boiling Point | 608.3ºC at 760mmHg |
Molecular Formula | C28H37FN2O |
Molecular Weight | 436.60500 |
Flash Point | 321.7ºC |
Exact Mass | 436.28900 |
PSA | 36.10000 |
LogP | 7.50570 |
Vapour Pressure | 9.6E-15mmHg at 25°C |
Index of Refraction | 1.562 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
Safety Phrases | S24/25 |
RIDADR | NONH for all modes of transport |
Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.
Bioorg. Med. Chem. 12(2) , 423-38, (2004) Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiol... |
|
Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.
Biochem. Pharmacol. 97 , 99-110, (2015) As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm... |
|
Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.
Br. J. Cancer 89(3) , 564-72, (2003) Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying mechanisms are still unknown. ... |
MFCD00467704 |
Fgin 1 27 |
Lopac-D-8555 |
Tocris-0658 |
N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide |