Domoic acid

Modify Date: 2024-01-05 19:11:19

Domoic acid Structure
Domoic acid structure
Common Name Domoic acid
CAS Number 14277-97-5 Molecular Weight 311.330
Density 1.3±0.1 g/cm3 Boiling Point 607.2±55.0 °C at 760 mmHg
Molecular Formula C15H21NO6 Melting Point 228ºC
MSDS Chinese USA Flash Point 321.0±31.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Domoic acid


Domoic acid ((-)-Domoic acid; L-Domoic acid) is an excitatory neurotransmitter isolated from a form of marine vegetation, Nitzschia pungens[1]. Domoic acid produces neurotoxic effect through activating kainate receptor[2].

 Names

Name domoic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 607.2±55.0 °C at 760 mmHg
Melting Point 228ºC
Molecular Formula C15H21NO6
Molecular Weight 311.330
Flash Point 321.0±31.5 °C
Exact Mass 311.136902
PSA 123.93000
LogP 0.61
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.545

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX9665100
CHEMICAL NAME :
3-Pyrrolidineacetic acid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, (2S-(2-alpha,3- beta,4-beta(1Z,3E,5S*)))-
CAS REGISTRY NUMBER :
14277-97-5
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H21-N-O6
MOLECULAR WEIGHT :
311.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 28,501,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg/9W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,525,1996

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
RIDADR UX9665100
RTECS UX9665100

 Synthetic Route

 Articles53

More Articles
Metal-organic framework UiO-66 modified magnetite@silica core-shell magnetic microspheres for magnetic solid-phase extraction of domoic acid from shellfish samples.

J. Chromatogr. A. 1400 , 10-8, (2015)

Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared s...

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.

Neurobiol. Dis. 70 , 74-89, (2014)

Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much stud...

Ursolic acid improves domoic acid-induced cognitive deficits in mice.

Toxicol. Appl. Pharmacol. 271(2) , 127-36, (2013)

Our previous findings suggest that mitochondrial dysfunction is the mechanism underlying cognitive deficits induced by domoic acid (DA). Ursolic acid (UA), a natural triterpenoid compound, possesses m...

 Synonyms

(3S,4S)-4-[(2Z,4E,6R)-6-Carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)-L-proline
L-Proline, 3-(carboxymethyl)-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-, (3S,4S)-
Domoic acid,(2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineaceticacid
[2S-[2a,3b,4b(1Z,3E,5S*)]]-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic Acid
Domoic acid
MFCD00040640
L-Domoic acid
(3S,4S)-4-[(2Z,4E,6R)-6-Carboxy-2,4-heptadien-2-yl]-3-(carboxymethyl)-L-proline
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Domoic acid suppliers

Domoic acid price