Usmarapride free base

Modify Date: 2024-01-14 10:48:44

Usmarapride free base structure	Common Name	Usmarapride free base
	CAS Number	1428862-32-1	Molecular Weight	383.487
	Density	1.3±0.1 g/cm3	Boiling Point	541.9±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₉N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	281.5±32.9 °C

Use of Usmarapride free base

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

Name	GNQ25KYD72
Synonym	More Synonyms

Description	Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT4 Receptor:44 nM (EC50)
In Vivo	Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT)[1]. Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia[1]. Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index[1]. Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats[1].
References	[1]. Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64(15):10641-10665.

Density	1.3±0.1 g/cm3
Boiling Point	541.9±60.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₉N₅O₂
Molecular Weight	383.487
Flash Point	281.5±32.9 °C
Exact Mass	383.232117
LogP	1.78
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.636

1H-Indazole, 3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-

1-Isopropyl-3-{5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl}-1H-indazole

GNQ25KYD72

DC Chemicals Limited
China
Product Name: Usmarapride free base
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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