YM543 free base
Modify Date: 2026-08-04 11:58:48
YM543 free base structure
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Common Name | YM543 free base | ||
|---|---|---|---|---|
| CAS Number | 655237-16-4 | Molecular Weight | 396.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YM543 free baseYM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2]. |
| Name | YM543 free base |
|---|
| Description | YM543 free base is a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor. YM543 free base reduces blood glucose levels. YM543 free base can be used in research of diabetes[1][2]. |
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| Related Catalog | |
| Target |
SGLT2 |
| In Vivo | YM543 free base (0-3 mg/kg; p.o.) 在 KK/Ay 2 型糖尿病小鼠中降低血糖水平并改善葡萄糖耐量，同时增加尿糖排泄，效果甚至在 12 小时后仍持续[1]。 Animal Model: KK/Ay 2 diabetic mice[1] Dosage: 0.1, 0.3, 1, and 3 mg/kg Administration: oral administration Result: Had a strong and sustained antihyperglycemic effect in both KK/Ay type 2 diabetic mice. Animal Model: Male Sprague–Dawley rats[1] Dosage: 1.0 and 3.0 mg/kg Administration: intravenous injection (1.0 mg/kg) and oral administration (3.0 mg/kg) Result: 1.19 Administration iv (1 mg/kg) po (3 mg/kg) T1/2 (h) 0.9 1.3 CLtot (L/h/kg) 2483 Vdss (L/kg) 3360 Cmax (ng/mL) 101 Tmax (h) 0.5 AUC0-inf (ng h/mL) 403 F % 29 |
| References |
| Molecular Formula | C23H24O6 |
|---|---|
| Molecular Weight | 396.43 |
| InChIKey | AGJJCLBOHJQGFA-ZQGJOIPISA-N |
| SMILES | OCC1OC(c2cc(Cc3cc4cccccc-4c3)ccc2O)C(O)C(O)C1O |
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Name: Antihyperglycemic activity in KK/Ay type-2 diabetic mouse model assessed as increase ...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2401404
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Name: Antihyperglycemic activity in KK/Ay type-2 diabetic mouse model assessed as reduction...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2401403
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Name: Antihyperglycemic activity in streptozotocin-induced type-1 diabetes mellitus rat mod...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2401402
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|
Name: Selectivity ratio of IC50 for human SGLT1 to IC50 for human SGLT2
Source: ChEMBL
Target: N/A
External Id: CHEMBL2401416
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Name: Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-methyl-alpha-D-glu...
Source: ChEMBL
Target: Sodium/glucose cotransporter 2
External Id: CHEMBL2401415
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Name: Half life in Sprague-Dawley rat at 3 mg/kg, po
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2401414
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|
Name: Half life in Sprague-Dawley rat at 1 mg/kg, iv
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2401413
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|
Name: AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2401408
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Name: Ratio of drug level in kidney to plasma in Sprague-Dawley rat at 1 mg/kg, iv and 3 mg...
Source: ChEMBL
Target: Nucleic Acid
External Id: CHEMBL2401407
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Name: Oral bioavailability in Sprague-Dawley rat at 3 mg/kg
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2401406
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