(+)-Dehydroabiethylamine

Modify Date: 2024-01-02 09:45:28

(+)-Dehydroabiethylamine Structure
(+)-Dehydroabiethylamine structure
Common Name (+)-Dehydroabiethylamine
CAS Number 1446-61-3 Molecular Weight 285.467
Density 1.0±0.1 g/cm3 Boiling Point 382.9±11.0 °C at 760 mmHg
Molecular Formula C20H31N Melting Point 44.50℃
MSDS Chinese USA Flash Point 156.7±9.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of (+)-Dehydroabiethylamine


Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity[1].

 Names

Name dehydroabietylamine
Synonym More Synonyms

 (+)-Dehydroabiethylamine Biological Activity

Description Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity[1].
Related Catalog
Target

CB1

CB2

References

[1]. Merarchi M, et, al. A Brief Overview of the Antitumoral Actions of Leelamine. Biomedicines. 2019 Jul 19;7(3):53.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 382.9±11.0 °C at 760 mmHg
Melting Point 44.50℃
Molecular Formula C20H31N
Molecular Weight 285.467
Flash Point 156.7±9.1 °C
Exact Mass 285.245636
PSA 26.02000
LogP 6.40
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.528
Storage condition Desiccate at +4°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP8701000
CHEMICAL NAME :
Podocarpa-8,11,13-trien-15-amine, 13-isopropyl-
CAS REGISTRY NUMBER :
1446-61-3
BEILSTEIN REFERENCE NO. :
3084620
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H31-N

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C: Corrosive;Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TP8701000
HS Code 3806900090

 Synthetic Route

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(+)-Dehydroabiethylamine Structure

(+)-Dehydroabie...

CAS#:1446-61-3

Literature: Svensk Kemisk Tidskrift, , vol. 66, p. 316,321

~%

(+)-Dehydroabiethylamine Structure

(+)-Dehydroabie...

CAS#:1446-61-3

Literature: Zhurnal Organicheskoi Khimii, , vol. 9, p. 756 - 758,778 - 780

~%

(+)-Dehydroabiethylamine Structure

(+)-Dehydroabie...

CAS#:1446-61-3

Literature: Tetrahedron, , vol. 53, # 42 p. 14355 - 14368

 Customs

HS Code 2921499090
Summary 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles1

More Articles
Synthesis of Tertiary and Quaternary Amine Derivatives from Wood Resin as Chiral NMR Solvating Agents.

Molecules 20 , 20873-86, (2015)

Chiral tertiary and quaternary amine solvating agents for NMR spectroscopy were synthesized from the wood resin derivative (+)-dehydroabietylamine (2). The resolution of enantiomers of model compounds...

 Synonyms

Leelamine hydrochloride,(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1-,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanaminehydrochloride
EINECS 215-899-7
MFCD00213430
(+)-DehydroabietylaMine [Optical Resolving Agent]
Dehydroabiethylamine
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