AGI-14100
Modify Date: 2023-01-17 07:40:53
AGI-14100 structure
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Common Name | AGI-14100 | ||
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| CAS Number | 1448346-43-7 | Molecular Weight | 599.971 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H22ClF4N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AGI-14100AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor; inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1); AGI-14100 can specifically induce cellular differentiation in AML patient samples with mutant IDH1 ex vivo; significantly reduces the leukemic blast burden in the peripheral blood in xenograft model with a primary human IDH1 R132H/FLT3-ITD tumor. |
| Name | AGI-14100 |
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| Description | AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor; inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1); AGI-14100 can specifically induce cellular differentiation in AML patient samples with mutant IDH1 ex vivo; significantly reduces the leukemic blast burden in the peripheral blood in xenograft model with a primary human IDH1 R132H/FLT3-ITD tumor. |
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| References | References 1. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159. 2. Kate Ellwood-Yen, et al. Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model. AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. View Related Products by Target Isocitrate Dehydrogenase (IDH) |
| Molecular Formula | C29H22ClF4N5O3 |
|---|---|
| Molecular Weight | 599.971 |