LP-935509

Modify Date: 2024-01-02 23:23:02

LP-935509 structure	Common Name	LP-935509
	CAS Number	1454555-29-3	Molecular Weight	396.44
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LP-935509

LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].

Name	LP-935509

Description	LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 3.3 nM (AAK1); 14 nM (BIKE); 320 nM (GAK)[1]
References	[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Molecular Formula	C₂₀H₂₄N₆O₃
Molecular Weight	396.44

DC Chemicals Limited
China
Product Name: LP-935509
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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