LP-44

Modify Date: 2024-01-05 11:22:04

LP-44 Structure
LP-44 structure
Common Name LP-44
CAS Number 824958-12-5 Molecular Weight 488.13
Density N/A Boiling Point N/A
Molecular Formula C27H38ClN3OS Melting Point N/A
MSDS USA Flash Point N/A

 Use of LP-44


LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration[1].

 Names

Name 6-[4-(2-methylsulfanylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide,hydrochloride
Synonym More Synonyms

 LP-44 Biological Activity

Description LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration[1].
Related Catalog
In Vivo LP44 (hydrochloride) (5.1, 10.3, 20.5, 41.0 nmol; i.c.v.) produces dose-dependent hypothermic effect in CBA mice[1].
References

[1]. Naumenko VS,et al. On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. Neuropharmacology. 2011 Dec;61(8):1360-5.

 Chemical & Physical Properties

Molecular Formula C27H38ClN3OS
Molecular Weight 488.13
Exact Mass 487.24200
PSA 60.88000
LogP 6.48050

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles1

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Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon.

PLoS ONE 6 , e24393, (2011)

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shap...

 Synonyms

Psalmotoxin 1
LP44,hydrochloride
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  • China
  • Product Name: LP-44
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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