JG26

Modify Date: 2024-01-21 17:50:32

JG26 Structure
JG26 structure
Common Name JG26
CAS Number 1464910-32-4 Molecular Weight 594.27
Density N/A Boiling Point N/A
Molecular Formula C19H22Br2N4O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JG26


JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively[1].

 Names

Name JG26

 JG26 Biological Activity

Description JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively[1].
Related Catalog
Target

ADAM17:1.9 nM (IC50)

ADAM8:12 nM (IC50)

ADAM10:150 nM (IC50)

MMP-9:>500000 nM (IC50)

MMP-8:240 nM (IC50)

MMP-9:1630 nM (IC50)

MMP-12:9.4 nM (IC50)

MMP14:19500 nM (IC50)

References

[1]. Doretta Cuffaro, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med Chem Lett. 2021 Oct 8;12(11):1787-1793.

 Chemical & Physical Properties

Molecular Formula C19H22Br2N4O6S
Molecular Weight 594.27